Scientific Evaluation of Ayurvedic Guggul Formulations: Therapeutic Applications, Pharmacodynamics and Pharmacokinetic Considerations
Abstract
Guggul, the oleo-gum resin derived from Commiphora mukul, is a cornerstone of Ayurvedic medicine known for its diverse therapeutic effects. Classical texts document several Guggul formulations - collectively termed Guggul Kalpans - which are customized by combining Guggul with other botanicals to target specific physiological derangements. This article critically reviews the different Guggul Kalpans, their active constituents, and the clinical scenarios in which they have been applied. An emphasis is placed on pharmacokinetic attributes such as absorption, distribution, metabolism, and excretion (ADME) of key compounds like guggulsterones, Active Constituents and Pharmacodynamics. The increasing synergy between traditional wisdom and modern research offers novel insights into potential integrative approaches for managing dyslipidemia, inflammatory disorders, and metabolic syndrome.
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References
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