Evaluation of Japakusumadi Yoga for safety profile - Acute Toxicity Profile

  • Dr. Suchetha Kumari M Associate Professor, Dept. of Prasooti Tantra and Stree Roga, Sri Dharmasthala Manjunatheshwar College of Ayurveda and Hospital, Udupi, Karnataka, India.
  • Sujata Kadam Tilak Ayurved Mahavidyalaya, Rastapet, Pune, Maharashtra, India.
  • Ravi Mundugaru Research Officer, Pharmacology Laboratory, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India.
  • Sudhakar Research Officer, Pharmacology Laboratory, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India.
  • B. Ravishankar Director, Pharmacology Laboratory, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India.
DOI: https://doi.org/10.21760/jaims.v2i06.340
Keywords: Japakusumadi Yoga, Mortality, Acute Oral Toxicity

Abstract

Japakusumadi Yoga is an Ayurvedic formulation, indicated for contraception in Ayurveda. This study determines acute toxicity of ‘Japakusumadi Yoga’ an oral formulation in wister albino rats. Single dose acute toxicity was assessed by employing OECD guidelines 425 using AOT software. Test formulations was administered to overnight fasted animals and 14 days observation of dosed (up down as per requirement) rats was done for general appearance, cage side behaviour including increased or decreasing motor activity, convulsions, straub’s reaction, catatonia, muscle spasm, spasticity, ophisthotonus, hyperesthesia, muscle relaxation, anaesthesia, arching and rolling, lacrimation, salivation, diarrhoea, writhing movement, mode of respiration and changes in skin colour etc., with mortality and autopsy finding in case of dead animal. Based on the observation made and recorded it can be concluded that the test drug is without any toxic potential even at the dose of 2000 mg/kg in animals equivalent to 22.4g for human being.

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CITATION
DOI: 10.21760/jaims.v2i06.340
Published: 2017-12-31
How to Cite
Dr. Suchetha Kumari M, Sujata Kadam, Ravi Mundugaru, Sudhakar, & B. Ravishankar. (2017). Evaluation of Japakusumadi Yoga for safety profile - Acute Toxicity Profile. Journal of Ayurveda and Integrated Medical Sciences, 2(06), 42-52. https://doi.org/10.21760/jaims.v2i06.340
Issue
Vol. 2 No. 06 (2017): NOV-DEC
Section
Original Article

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