Acute and Subacute Toxicity Study of Lehana Yogas in Wistar Albino Rats

  • Lara Dias Post Graduate Scholar, Department of PG studies in Kaumarabhritya, Sri Dharmastahala Manjunatheshwara College of Ayurveda, Udupi, Karnataka, India.
  • Sharaschandra R Associate Professor, Department of PG studies in Kaumarabhritya, Sri Dharmastahala Manjunatheshwara College of Ayurveda, Udupi, Karnataka, India.
  • Nagartna SJ Associate Professor, Department of PG studies in Kaumarabhritya, Sri Dharmastahala Manjunatheshwara College of Ayurveda, Udupi, Karnataka, India.
  • Sudhakar Bhat Research Officer, SDM Research center for Ayurveda and Allied sciences, Kuthpady, Udupi, Karnataka, India.
Keywords: Lehana, Suvarna Bhasma, Ghrita, Madhu, Vacha Churna, Amalaki Churna.

Abstract

Lehana Yogas is an Ayurvedic preparation which are known to enhance growth and development by providing sufficient nutrition and promoting health with improving intellect and speech and administered frequently with ghee and honey to children’s as immune boosters. In this study we assessed the safety parameters of the Lehana Yogas mentioned and its effect on acute and subacute administration in Wistar albino rats. The Wistar strain albino rats were divided into group of five, vehicle group of Ghrita-Madhu, Ghrita-Madhu with Suvarna Bhasma, Ghrita-Madhu -Suvarna Bhasma with Vacha Churna, Ghrita-Madhu -Suvarna Bhasma with Amalaki Churna, respectively. The duration of administration was for 28 days. During the course of study, no mortality and no significant behavioral changes were noticed in any group studied. No major alterations were observed in hematology and serum biochemistry reports. Histopathology of vital organs also shown no toxic effects. Materials and Methods: Thirty albino rats of either sex were selected and assigned to 5 groups of 6 each. Drugs will be administered for the duration of 28 days and will be assessed for toxicity profile at the end of the study. Result: Animals who were administered daily with Lehana Yogas for longer duration did not show any mortality. Hence, it indicates safer use of drugs in terms acute and subacute level of administration. Discussion: It is concluded that the administration of Lehana Yogas is safe and non-toxic at the tested dose levels.

Downloads

Download data is not yet available.

References

Tewari P.V, English translation on Kasyapa-Samhita Or Vrddhajivakiya Tantra of Kasyapa. Reprint edition. Sutrasthana; Lehana adhyaya: Chapter 18, verse 4. Varanasi: Chaukhambha Visvabharati, 2008; pg 3.

K.S. Dinesh. Kaumarabhrtya Updated. New Delhi: Chaukhambha Publications; 2016. Vol I. Chapter 4, Navajaatasisuparicharya; pg 64.

Acharya Shrinidhi Kumar, Acharya’s Text Book of Kaumarabhritya, Vol 2, Varanasi: Chaukhambha Orientalia, Chapter 43, Lehana in Kaumarbhritya, pg 660.

Sharma P.V, English translation on Caraka-Samhita of Agnivesa. Reprint edition. Sutrasthana; Jaatisutriyam shaeeram: Chapter 8, verse 46. Varanasi: Chaukhambha Orientalia, 2010; pg 480.

Tewari P.V, English translation on Kasyapa-Samhita Or Vrddhajivakiya Tantra of Kasyapa. Reprint edition. Sutrasthana; Lehana adhyaya: Chapter 18, verse 25.2-28. Varanasi: Chaukhambha Visvabharati, 2008; pg 7.

Murthy K.R. Srikanthu, English translation on Astanga Samgraha Of Vagbhata. Reprint edition. Uttara Sthana; Balopacaraniya: Chapter 1, verse 96. Varanasi: Chaukhambha Orientalia, 2009;pg 14

Murthy K.R. Srikantha. English translation on Astanga Hrdayam of Vagbhata. Fifth edition. Uttara Sthana; Balopacaraniya Adhyaya: Chapter 6. Verse 9. Varanasi: Chowkhamba Krishnadas Academy, 2010; pg 4

Anonymous, The Ayurvedic Formulary of India, Part I, (Department of Indian System of Medicines and Homeopathy, Ministry of Health and Family Welfare, GOI, New Delhi), 2003,247.

Paget GE and Barens JM, Evaluation of drug activities, In: Pharmacoetrics, Vol. I, (Ed. Lawrence DR and Bacharch AL; Academic Press, New York), 1964,161.

Lavekar GS, Ravishankar B, Gaidhani S, Shukla VJ, Ashok BK, and Padhi MM, Mahayogaraja guggulu: Heavy metal estimation and safety studies. Int J Ayurveda Res, 1 (2010)150.

CITATION
DOI: 10.21760/jaims.7.7.11
Published: 2022-09-11
How to Cite
Lara Dias, Sharaschandra R, Nagartna SJ, & Sudhakar Bhat. (2022). Acute and Subacute Toxicity Study of Lehana Yogas in Wistar Albino Rats. Journal of Ayurveda and Integrated Medical Sciences, 7(7), 80 - 89. https://doi.org/10.21760/jaims.7.7.11
Section
Original Article