Experimental Study of Manjistha root (Rubia cordifolia Linn.) w.s.r. to Anti-Diabetic Activity

Dr. Ankita Patil; Dr. Shashidhar Naik; Dr. Darshan N. Dhari

doi:10.21760/jaims.v3i03.406

Dr. Ankita Patil Post Graduate Scholar, Dept. of Dravya Guna, BLDEA’s AVS Ayurveda Mahavidyalaya Hospital & Research Centre, Vijayapur, Karnataka, India.
Dr. Shashidhar Naik Professor & Head, Dept. of Dravya Guna, BLDEA’s AVS Ayurveda Mahavidyalaya Hospital & Research Centre, Vijayapur, Karnataka, INDIA.
Dr. Darshan N. Dhari Associate Professor, Dept. of Dravya Guna, BLDEA’s AVS Ayurveda Mahavidyalaya Hospital & Research Centre, Vijayapur, Karnataka, INDIA.

DOI: https://doi.org/10.21760/jaims.v3i03.406

Keywords: Manjistha, Rubiacordifolia, Experimental Study, Anti-Hyperglycemic Activity

Abstract

Manjistha is well known for its various activities, one of which is Pramehagna (Anti-Diabetic) activity. The Manjistha was collected from market and its authenticity was approved by its organoleptic characters and is used for present study. The sample was processed and it’s alcoholic and aqueous extracts were prepared. Then the drug was subjected to experimental study on albino rats. Study was carried out to assess the anti-diabetic activity. Results showed that there is significant reduction in sugar level which indicates that both aqueous and alcoholic extracts do possess significant antihyperglycemic activity as compared to Metformin (Standard drug), which could be due to antioxidants and flavonoids present in it. The variations in above said analysis make it very interesting and important to analyse the expected Anti-microbial and immune modulatory activity of Manjistha root.

Downloads

Download data is not yet available.

References

Wild S, Roglic G, Green A, Sicree R, King H (may 2004). “Global prevalence of diabetes: estimates for the year 2000 and projections for 2030”.Diabetic Care. 27:1047- 53.

About Diabetes. World Health Organization. Archived from the original on 31 March 2014. Retrived 4 April 2014.

Y. G. Joshi, Charak Samhita, part 2, 3rd edition, 2011,p.184.

Sushruta : Sushruta Samhita, Nirayasagar Press, Bombay.

Priyavrat Sharma, Priya Nighantu, Padama hindi commentary. 2nd edition, Chaukambha Surabharati Prakashana, Varanasi, 1995:46

Chunekar K. C., Bhavmishra’s Bhavprakash Nighantu, Varanasi: Chaukambha Bharati Academy, reprinted 2002.

Sharma P.V. Dhanvantari Nighantu. Varanasi: Chaukhambha Surabharathi, 1982.

Sharma P.V. Kaiyadeva Nighantu, Varanasi, Chaukambha orientalia,1982.

Vaidya Bapalal G. Nighantu Adarsha, Vol 2, 2nd edition, Varanasi: Chaukambha Bharati Academy 1985.

Joharapurkar AA, Zambad SP, Wanjari MM, Umathe SN. In vivo evaluation of antioxidant activity alcoholic extract of Rubiacordifolia. Indian Journal of Pharmacology 2003; 35: 232 – 236.

Valianthan, MS. Healing Plants Current Sciences 1975; 1122-26p.

Shanmugasundaram KR, Panneerselvam SP, Shanmugasundaram ERB. The effect of Gymnemasylvestrae on enzyme changes and glucose utilization in diabetic rabbit. J. Ethnopharmacol 1983; 7: 205-216.

Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinosporacordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. Journal of Ethnopharmacol 2000; 73: 461- 70.

Sabu MC, Kuttan Ramadasan. Antidiabetic activity of Aeglemarmelos and its relationship with antioxidant properties. Indian J PhysiolPharmacol 2004; 48 (1): 81– 88.

Joharapurkar AA, Zambad SP, Wanjari MM, Umathe SN. In vivo evaluation of antioxidant activity alcoholic extract of Rubiacordifolia. Indian Journal of Pharmacology 2003; 35: 232 – 236.