particularly the brain, scalp, sinuses, face skin, and hair roots, is highlighted by this idea. According to traditional Ayurvedic doctors, pharmaceutical oils or powders administered through the nose might directly reach and calm the head region's morbid Doshas, resulting in both therapeutic and restorative benefits.[8,9]
A. Neurovascular Interaction
The limbic system and olfactory bulb, which are involved in emotion, hormone control, and skin homeostasis, are directly connected to the olfactory area, which is located at the roof of the nasal cavity. In addition, the forehead, scalp, cheeks, and jaw line are innervated by the trigeminal nerve (CN V), which is often implicated in cosmetic issues such as dullness, hair loss, and acne.[10]
The nasal mucosa and the facial skin and scalp share sensory pathways through the ophthalmic (V1), maxillary (V2), mandibular (V3) branches.
These brain pathways contribute to neurogenic inflammation and skin aging in addition to transmitting sensory information. Nasya may affect local circulation and cellular healing pathways by stimulating these nerve terminals.[11]
B. Detox and Lymphatic Pathways
Similar to mucosal immune systems (such as the gut's GALT), the nasal-associated lymphoid tissue (NALT) aids in systemic detoxification and immune monitoring. Daily Pratimarsha Nasya may help eliminate inflammatory mediators and metabolic waste products, which would lessen skin dullness, pigmentation, and puffiness on the face. Additionally, because medicinal oils are lipophilic, they readily permeate the epithelial lining and affect sebaceous gland function, perhaps repairing the health of the scalp and averting follicular damage, seborrhea, or dandruff.
C. Regulation of Hormones and Stress
Bypassing the blood-brain barrier and reaching the hypothalamus and pituitary gland directly, intranasal medication delivery can control hormones related to stress response, melanin synthesis, and hair growth cycles.[12] For instance, long-term stress raises cortisol, which impacts the function of the skin barrier and encourages telogen effluvium, or hair loss. Nasya oils containing Brahmi, Shankhapushpi, or Jatamansi may alter this axis, lowering stress-related skin and hair conditions.
3. Delivery Paths from the Nose to the Brain
Effective channels for nasal drug delivery systems (NDDS) are provided by the physiological makeup of the brain and nasal cavity. Drug molecules get past the olfactory or respiratory epithelium barriers via a variety of pathways before being administered via the nose at the pial brain surface. The chemicals can spread to other central nervous system (CNS) tissues after entering the brain.
Three main trafficking channels have been discovered as of right now:
1. The Blood Circulation Route
2. The pathway of the trigeminal nerve
3. The Pathway of the Olfactory Nerve
After being absorbed in the nasal cavity, drugs may proceed to the cerebrospinal fluid (CSF) via the trigeminal nerve or olfactory bulb before arriving in the brain. As an alternative, the medication might enter the bloodstream through the respiratory or gastrointestinal tract before passing through the blood-brain barrier (BBB).[13]
A. The Olfactory Pathway
There are two parts to the olfactory system: the extracellular and intracellular routes.
- Intracellular Pathway: Also known as the olfactory nerve pathway, this starts when nanoparticles are internalized by olfactory receptor neurons. These are exocytosed by mitral cells and transported by endocytic vesicles in olfactory ensheathing cells (OECs).[14]
- Extracellular Route: transcellular pathway, which can be facilitated by receptor-mediated endocytosis or passive diffusion over the SUS membrane, is appropriate for hydrophobic nanoparticles.[15]
B. The Trigeminal Nerve System
The largest cranial nerve is the trigeminal nerve (cranial nerve V), which has three main branches: the mandibular, maxillary, and ophthalmic.[16]
C. The Pathway of Blood Circulation
Because lamina propria of nasal mucosa is densely packed with lymphatic & blood capillaries, drugs can enter systemic circulation more quickly. Low molecular weight lipophilic compounds can therefore penetrate blood-brain barrier & enter brain.[17]