A Comparative Clinical Study to Evaluate the Efficacy of Madhukadi Ghrita and Samangadi Leha in enhancing Vyadhikshamatva w.s.r. to Immunity in Children

Rohini Dharwal; Karam Singh; Rakesh Sharma

doi:10.21760/jaims.10.5.3

E-ISSN:2456-3110

Research Article

Immunity in Children

Journal of Ayurveda and Integrated Medical Sciences

2025 Volume 10 Number 5 MAY

Publisher

www.maharshicharaka.in

A Comparative Clinical Study to Evaluate the Efficacy of Madhukadi Ghrita and Samangadi Leha in enhancing Vyadhikshamatva w.s.r. to Immunity in Children

Dharwal R^1*, Singh K², Sharma R³

DOI:10.21760/jaims.10.5.3

^1* Rohini Dharwal, Assistant Professor, Department of Kaumarbhritya, Abhilashi Ayurvedic Medical College and Research Institute, Chail-Chowk, Mandi, Himachal Pradesh, India.

² Karam Singh, Lecturer, PG Department of Kaumarbhritya, Rajiv Gandhi Government Post Graduate Ayurvedic College and Hospital, Paprola, Himachal Pradesh, India.

³ Rakesh Sharma, Head, PG Department of Kaumarbhritya, Rajiv Gandhi Government Post Graduate Ayurvedic College and Hospital, Paprola, Himachal Pradesh, India.

Background: Despite tremendous progress in recent decades, infectious diseases remain a leading cause of morbidity and mortality in pediatric population worldwide. Optimal immune health directly depends upon Hitakara Aahar and Vihar. Maintaining a diet and lifestyle aligned with one’s Satmya help strengthening the defense mechanism of the body. Equilibrium of Doshas, Bala and Ojas capable of effectively combating disease. Strengthening the immune system in a natural way there are many formulations like Rasayana, Balya and Ojovridhikara drugs.

Aims and Objective: To evaluate, compare the efficacy and clinical safety of Madhukadi Ghrita and Samangadi Leha in children.

Materials and Methods: A randomized, comparative clinical trial was conducted on 40 pediatric patients belonging to age group 2-10 years for 4 weeks who were suffering from recurrent RTI and GIT infections. The patients were divided into two groups: Group I received Madhukadi Ghrita, while Group II was treated with Samangadi Leha. The clinical efficacy of both interventions was assessed based on subjective and objective criteria, symptomatic relief and overall improvement.

Results: Both groups significantly improved clinical symptoms. Madhukadi Ghrita is preferable for immediate symptom alleviation, whereas Samangadi Leha is beneficial for long-term immune system support.

Conclusion: This study seeks to provide safe and effective Ayurvedic alternatives for enhancing Vyadhikshamatva (immunity) in children, fostering long-term immune resilience and overall well-being.

Keywords: Vyadhikshamatva, Balya, Immunity, Madhukadi Ghrita, Samangadi Leha

Corresponding Author	How to Cite this Article	To Browse
Rohini Dharwal, Assistant Professor, Department of Kaumarbhritya, Abhilashi Ayurvedic Medical College and Research Institute, Chail-Chowk, Mandi, Himachal Pradesh, India. Email:	Dharwal R, Singh K, Sharma R, A Comparative Clinical Study to Evaluate the Efficacy of Madhukadi Ghrita and Samangadi Leha in enhancing Vyadhikshamatva w.s.r. to Immunity in Children. J Ayu Int Med Sci. 2025;10(5):11-19. Available From https://jaims.in/jaims/article/view/4321/

Manuscript Received	Review Round 1	Review Round 2	Review Round 3	Accepted
2025-04-06	2025-04-26	2025-05-06	2025-05-16	2025-05-26
Conflict of Interest	Funding	Ethical Approval	Plagiarism X-checker	Note
None	Nil	Yes	12.63

© 2025 by Dharwal R, Singh K, Sharma R and Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

J Ayu Int Med Sci 2025;10(5)11

Download PDF Back To Article Introduction Aim and Objectives Materials and Methods Results Discussion Conclusion References

Rohini Dharwal et al. Efficacy of Madhukadi Ghrita and Samangadi Leha

Introduction

Globally, infectious diseases, including pneumonia, diarrhoea and malaria, remain a leading cause of under-five deaths, along with preterm birth and intra-partum related complications.^[1]

Frequent, prolonged, or severe infections indicate immunodeficiency. Recurrent respiratory and gastrointestinal infections are common in children, ranging from mild to severe conditions. Factors like an immature immune system, environmental exposures, and nutritional deficiencies contribute to their high prevalence.

Immunity refers to the body’s ability to resist or defend against harmful foreign substances such as bacteria, viruses and other pathogenic agents. The inherent defence mechanisms that are present in an individual even before first exposure to pathogen are known as innate or natural immunity.^[2]

The concept of strong immune system is thought to be a result of well functioning bodily systems and the presence of balanced state of three Doshas (Vata, Pitta and Kapha). The key principles of immunity include Aahar, Lehana, Dinacharya, Ritucharya, Yogasana, Pranayam and Medhya Rasayana. Maintaining a diet and lifestyle aligned with one’s Satmya help strengthen the natural defense mechanism of the body. This alignment ensures that the body is well nourished, balanced and capable of effectively combating disease.^[3]

Immunomodulatory drugs are classified into categories such as Rasayana, Balya and Ojovridhikara.^[4]

Many plant-based compounds with potential immunotherapeutic effects have been discovered, validating their use in traditional medicine and paving the way for future research. The ingredients of these selected formulations form a distinctive blend possessing Balya (strengthening), Medhya (intellect-enhancing) and Rasayana (rejuvenating) properties.^[5]

Considering the aforementioned factors and aiming to relieve children from restlessness, exasperation and discomfort, a dedicated effort has been made in the present study titled “A Comparative Clinical Study to Evaluate the Efficacy of Madhukadi Ghrita and Samangadi Leha in enhancing Vyadhikshamatva w.s.r. to Immunity in Children.”

Aim and Objectives

1. To study the efficacy of Madhukadi Ghrita and Samangadi Leha on Vyadhikshamatva in children.
2. To compare the efficacy of Madhukadi Ghrita and Samangadi Leha.
3. To evaluate the clinical safety of Madhukadi Ghrita and Samangadi Leha in children.

Materials and Methods

Total 40 patients were registered from the Kaumarbhritya-Balroga OPD/IPD, RGGPG Ayurvedic College and Hospital, Paprola, randomly fulfilling the criteria of this study.

A case proforma was filled with the data obtained by interrogation, physical examination and collection of details of each child.

Inclusion Criteria

1. Patient between 2 to 10 years of Age.
2. Patient suffering from recurrent GIT and RTIs.
3. Patient /Parents willing to participate in the trial.

Exclusion Criteria

1. Patient below 2 years of age and above 10 years.
2. Patients with congenital, hereditary or acute systemic illness (Jaundice, Hypothyroidism, Renal impairments and Electrolyte imbalance).
3. Patient with physical disability.

Grouping of Patients

In the present research work, a total of 40 patients were registered and studied under two groups.

Group-I

20 patients in this group were managed with Madhukadi Ghrita.

Route of Administration: Oral
Dosage: 5ml/kg/day in two divided doses.
Anupana: Lukewarm Milk.

Group-II

In this group 20 patients were given the trial drug Samangadi Leha.

Route of Administration: Oral
Dosage: 500mg/kg/day in two divided doses.
Anupana: Lukewarm Milk.

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Rohini Dharwal et al. Efficacy of Madhukadi Ghrita and Samangadi Leha

Duration of the trial: 4 weeks

Follow-up: 2^nd, 4^th week and subsequent follow ups on 8^th, 12^th week

Criteria of Assessment of Results

The assessment of the effect of trial drugs was done based on the subjective and objective criteria. All the patients were examined before initiation and after completion of the trial.

The improvement was assessed based on relief in severity of symptoms and changes in laboratory investigations were also taken into consideration.

Subjective Criteria

All the sign & symptoms depending upon their severity and frequency were graded on 4-point scale i.e., 0,1,2,3. The clinical improvement during and after trial were correlated with the previous grading of sign and symptoms.

Table 1: Grading of sign and symptoms.

Illness			Grade
Temperature	Severity
	Nil		0
	Slight fever and /or some aches		1
	Definite elevation of temperature, moderate aches, headache		2
	Severely incapacitated by general symptoms		3
	Frequency
	Nil		0
	1 episode in last 3 months		1
	2 episodes in last 3 months		2
	>=3 episodes in last 3 months		3
Running Nose		Severity
		Nil	0
		Mild discharge, stuffiness, sneezing	1
		Heavy, clear discharge and /or stuffiness	2
		Yellow or green nasal discharge	3
		Frequency
		Nil	0
		1 episode in last 3 months	1
		2 episodes in last 3 months	2
		>=3 episodes in last 3 months	3
Cough		Severity
		No cough	0
		Mild, isolated cough, without additional symptoms	1
		Moderate, paroxysmal cough, without additional symptoms	2
		Severe, strenuous cough, accompanied by chest discomfort	3
		Frequency
		Nil	0
		1 episode in last 3 months	1
		2 episodes in last 3 months	2
		>=3 episodes in last 3 months	3
Sore Throat		Severity
		Normal	0
		Throat discomfort	1
		Pain in throat with difficulty in swallowing of food	2
		Pain in throat and difficulty in swallowing even saliva	3
		Frequency
		Nil	0
		1 episode in last 3 months	1
		2 episodes in last 3 months	2
		>=3 episodes in last 3 months	3

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	Frequency
Tonsils	Severity
	Normal	0
	Enlarged without inflammation	1
	Enlarged with inflammation	2
	Yellowish spot on tonsils	3
	Nil	0
	1 episode in last 3 months	1
	2 episodes in last 3 months	2
	>=3 episodes in last 3 months	3
Pain Abdomen	Severity
	No pain	0
	Mild pain (Nagging, annoying, interfering little with ADLs)	1
	Moderate pain (interferes significantly with ADLs)	2
	Severe pain (Disabling, Unable to perform ADLs)	3
	Frequency
	Nil	0
	1 episode in last 3 months	1
	2 episodes in last 3 months	2
	3 episodes in last 3 months	3
Vomiting	Severity
	Nil	0
	Forceful ejection of small amount of gastric contents (Milk/Food)	1
	Projectile Vomiting (Large amount of gastric content)	2
	Bilious Vomiting (containing large amount of bile)	3
	Frequency
	Not any episode	0
	1-2 episodes in last 3 months	1
	3-5 episodes in last 3 months	2
	4-6 or more episodes in last 3 months	3
Loose Stools	Severity
	Nil	0
	2-3 stools above normal per day	1
	4-6 stools above normal per day	2
	>=7 stools above normal per day	3
	Frequency
	Nil	0
	1 episode in last 3 months	1
	2episodes in last 3 months	2
	3episodes in last 3 months	3

Objective Criteria

Serum IgG

Laboratory investigations

CBC (Hb gm%, TLC, DLC)
ESR
LFT (SGOT, SGPT)

Statistical Analysis

Data was statistically analyzed by using appropriate tests “Student’s paired ‘t’ test” for individual group and “Unpaired ‘t’ test” for intergroup comparison were used for parametric data.

For non-parametric data “Wilcoxon Signed Rank Sum test” was used for ind. group & “Mann Whitney ‘U’ test” was used for intergroup comparison.

The obtained results were interpreted as follows:

Highly significant p<0.001
Significant p<0.05
Insignificant p>0.05

Assessment of Results

Marked improvement	75% - 100% relief
Moderate improvement	51% - 74% relief
Mild improvement	25% - 50% relief
No improvement	<25% relief

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Results were assessed based on the overall effect of the trial drugs on subjective as well as objective parameters and categorized as;

Results

Table 2: Therapy effect on subjective parameters depending upon their severity (before and after treatment)

Signs and symptoms	Groups	Mean		d	% Relief	SD±	SE±	W value	p value
Signs and symptoms	Groups	BT	AT	d	% Relief	SD±	SE±	W value	p value
Fever	Group I	1	0.2	0.8	80%	0.696	0.156	-91	<0.001
Fever	Group II	0.8	0.1	0.7	87.5%	0.801	0.179	-55	0.002
Running Nose	Group I	0.35	0.1	0.25	71.42%	0.550	0.123	-10	0.125
Running Nose	Group II	0.6	0.05	0.55	91.66%	0.825	0.184	-28	0.016
Cough	Group I	0.6	0.2	0.4	66.66%	0.598	0.134	-28	0.016
Cough	Group II	1.5	0.35	1.1	73.33%	0.788	0.176	-136	<0.001
Sore Throat	Group I	0.65	0.15	0.5	76.92%	0.688	0.154	-36	0.008
Sore Throat	Group II	0.5	0	0.5	100%	0.606	0.135	-45	0.004
Tonsils	Group I	0.35	0.1	0.25	71.42%	0.444	0.099	-15	0.063
Tonsils	Group II	0.7	0.5	0.2	28.57%	0.410	0.091	-10	0.125
Pain Abdomen	Group I	1.35	0.5	0.85	62.96%	0.587	0.131	-120	<0.001
Pain Abdomen	Group II	0.5	0.15	0.35	70%	0.489	0.109	-28	0.016
Vomiting	Group I	0.55	0	0.55	100%	0.686	0.153	-45	0.004
Vomiting	Group II	0.35	0.05	0.3	85.71%	0.470	0.105	-21	0.031
Loose Stools	Group I	0.5	0.05	0.45	90%	0.604	0.135	-36	0.008
Loose Stools	Group II	0.15	0	0.15	100%	0.366	0.081	-6	0.250

Table 3: Therapy effect on subjective parameters depending upon their frequency (before and after treatment)

Signs and symptoms	Groups	Mean		d	% Relief	SD±	SE±	W value	p value
Signs and symptoms	Groups	BT	AT	d	% Relief	SD±	SE±	W value	p value
Fever	Group I	0.9	0.15	0.75	83.33%	0.64	0142	-91	<0.001
Fever	Group II	0.7	0.15	0.55	78.57%	0.686	0.153	-45	0.004
Running Nose	Group I	0.4	0.15	0.25	62.5%	0.444	0.099	-15	0.125
Running Nose	Group II	0.55	0.1	0.45	81.81%	0.686	0.153	-28	0.016
Cough	Group I	0.75	0.2	0.55	73.33%	0.76	0.169	-36	0.008
Cough	Group II	1.45	0.6	0.85	58.62%	0.587	0.131	-120	<0.001
Sore Throat	Group I	0.7	0.15	0.55	78.57%	0.83	0.184	-36	0.008
Sore Throat	Group II	0.7	0.25	0.45	64.28%	0.510	0.114	-45	0.004
Tonsils	Group I	0.45	0.15	0.3	66.66%	0.571	0.127	-15	0.063
Tonsils	Group II	1	0.5	0.5	50%	0.688	0.153	-36	0.008
Pain Abdomen	Group I	1.4	0.6	0.8	57.14%	0.523	0.116	-120	<0.001
Pain Abdomen	Group II	0.7	0.35	0.35	50%	0.489	0.109	-28	0.016
Vomiting	Group I	0.5	0	0.5	100%	0.606	0.136	-45	0.004
Vomiting	Group II	0.35	0.05	0.3	85.71%	0.759	0.169	-21	0.031
Loose Stools	Group I	0.6	0.2	0.4	66.66%	0.598	0.133	-28	0.016
Loose Stools	Group II	0.25	0	0.25	100%	0.638	0.142	-6	0.250

Table 4: Inter-group comparison of subjective parameters

Morbidity Features	Mean diff. (BT-AT)			Diff. in % Relief	Mann Whitney Rank	p value
Morbidity Features		Group I	Group II	Diff. in % Relief	Mann Whitney Rank	p value
Fever	Severity	0.8	0.7	-7.5%	429	0.616
Fever	Frequency	0.75	0.55	4.73%	446	0.336
Running Nose	Severity	0.25	0.55	-20.24%	375	0.355
Running Nose	Frequency	0.25	0.45	-19.31%	385	0.506
Cough	Severity	0.4	1.1	-6.67%	313	0.009
Cough	Frequency	0.55	0.85	14.71%	354	0.136
Sore Throat	Severity	0.5	0.5	-23.08%	405	0.903
Sore Throat	Frequency	0.55	0.45	14.29%	409	0.989

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Rohini Dharwal et al. Efficacy of Madhukadi Ghrita and Samangadi Leha

Tonsils	Severity	0.25	0.2	42.85%	420	0.796
Tonsils	Frequency	0.3	0.5	16.66%	379	0.408
Pain Abdomen	Severity	0.85	0.35	-7.04%	497	0.019
Pain Abdomen	Frequency	0.8	0.35	7.14%	493	0.024
Vomiting	Severity	0.55	0.3	14.29%	446	0.335
Vomiting	Frequency	0.5	0.3	14.29%	443	0.378
Loose Stools	Severity	0.45	0.15	-10%	461	0.166
Loose Stools	Frequency	0.4	0.25	-40%	444.5	0.355

Table 5: Effect of therapy on objective criteria (Difference observed before and after treatment)

Investigation	Groups	Mean		d	% change	SD±	SE±	‘t’ value	p value
Investigation	Groups	BT	AT	d	% change	SD±	SE±	‘t’ value	p value
IgG	Group I	10.65	10.71	-0.06	-0.56%	0.521	0.116	-0.519	0.610
IgG	Group II	9.797	10.58	-0.783	-7.99%	1.006	0.224	-3.480	0.003

Table 6: Intergroup comparison of objective criteria

Investigation	Mean diff (BT-AT)		Diff. in % Relief	‘t’value	p value
Investigation	Group I	Group II	Diff. in % Relief	‘t’value	p value
IgG	-0.06	-0.783	13.05%	2.852	0.007

Table 7: Effect of therapy on laboratory parameters

Investigation	Groups	Mean		d	% change	SD±	SE±	‘t’value	p value
Investigation	Groups	BT	AT	d	% change	SD±	SE±	‘t’value	p value
Hb	Group I	12.84	13.135	-0.295	-2.297	0.787	0.176	-1.676	0.110
Hb	Group II	12.465	12.515	-0.05	-0.401	1.02	2.24	0.218	0.830
TLC	Group I	6.396	5.788	0.608	9.505	1.996	0.446	1.363	0.189
TLC	Group II	7.773	6.264	1.51	19.43	2.605	0.582	2.593	0.018
NEU	Group I	58.76	54.25	4.51	7.675	13.4	2.996	1.505	0.149
NEU	Group II	62.285	54.29	7.995	12.84	9.776	2.186	3.657	0.002
LYM	Group I	33.46	31.57	1.89	5.648	13.519	3.023	0.625	0.539
LYM	Group II	31.33	33.895	-2.565	-8.187	8.234	1.841	1.393	0.180
MID	Group I	5.145	5.33	-0.185	-3.595	1.723	0.385	-0.480	0.637
MID	Group II	5.32	5.705	-0.385	-7.236	1.97	0.441	-0.874	0.393
ESR	Group I	11.1	8.35	2.75	24.77	8.245	1.844	1.492	0.415
ESR	Group II	11.7	11.9	-0.2	-1.709	8.089	1.809	-0.111	0.913
SGOT	Group I	25.9	27.4	-1.5	-5.791	8.043	1.798	-0.834	0.415
SGOT	Group II	34.2	28.1	6.1	17.84	17.072	3.817	1.598	0.127
SGPT	Group I	18.9	22.35	-3.45	-18.25	10.865	2.43	-1.420	0.172
SGPT	Group II	25.2	20.65	4.55	18.06	20.786	4.648	0.979	0.340

Table 8: Intergroup comparison of laboratory parameters

Investigations	Mean diff. (BT-AT)		Diff. in % Relief	‘t’value	p value
Investigations	Group I	Group II	Diff. in % Relief	‘t’value	p value
Hb	-0.295	-0.05	-1.896%	-0.847	0.402
TLC	0.608	1.51	-9.925%	-1.229	0.227
NEU	4.51	7.995	-5.165%	-0.940	0.353
LYM	1.89	-2.565	13.84%	1.259	0.216
MID	-0.185	-0.385	3.641%	0.342	0.734
ESR	2.75	-0.2	26.48%	1.142	0.261
SGOT	-1.5	6.1	-23.63%	-1.801	0.080
SGPT	-3.45	4.55	-36.31%	-1.525	0.135

Discussion

Subjective Parameters

Group I (Madhukadi Ghrita) showed a highly significant improvement in fever, abdominal pain (severity) and the frequency of fever and cough.

Significant improvements were also observed in the severity of cough, sore throat, vomiting and loose stools, as well as in the frequency of abdominal pain, sore throat and tonsillitis. However, the results were insignificant for the severity of running nose and tonsillitis, as well as the frequency of running nose and loose stools.

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Group II (Samangadi Leha) showed a highly significant improvement in cough (both in severity and frequency). Other morbidity features showed significant results, while the changes in tonsils, loose stool severity, and frequency of a running nose were not statistically significant.

In the intergroup comparison, a statistically significant difference was observed in cough relief (severity) and pain abdomen (severity and frequency). Group II demonstrated superior results for cough relief, while Group I showed better outcomes for pain abdomen. Other subjective parameters in intergroup comparison showed insignificant result between the two Groups.

Objective Parameters

Group I showed minimal impact on IgG levels, whereas Group II exhibited a statistically significant increase, indicating stronger immunomodulatory effects. Intergroup analysis revealed a significant difference (p < 0.05), confirming the superior efficacy of Group II in enhancing IgG levels.

Group II showed a significant reduction in TLC and neutrophil levels, while changes in hemoglobin, lymphocytes, MID counts, ESR, and liver enzymes (SGOT, SGPT) were not statistically significant in either group. Intergroup comparison revealed no significant differences in any parameter, indicating a similar impact in both groups.

Probable mode of action of the trial drugs-

1. Madhukadi Ghrita

Table 9: Pharmacological actions

Ingredients	Karma	Action based on pharmacological studies
Madhuka	Balya, Vatapittajita, Swarya	Anti-tussive, Anti-inflammatory, Anti-microbial, Hepatoprotective, Immunomodulatory
Vacha	Kanthya, Deepani, Vatahara, Kaphahara, Agnivardhaka	Anti- inflammatory, Anti-bacterial, Broncho-dilation, Immunomodulatory, Neurologic effect
Pippali	Kaphavatashamaka, Deepana, Ruchya, Kasahara, Rasayana, Balya	Anti-microbial, effect on Respiratory System, Immunomodulatory, Anti-tumor, Hepatoprotective
Chitraka	Deepana, Pachana, Grahi, Kanthya, Jwaraghna, Rasayana	Anti-inflammatory, Antimicrobial, Antioxidant,Nephroprotective, Hepatoprotective
Haritki	Deepana, Pachana, Anulomana, Grahi, Kaphaghna, Srotah-shodhana, Rasayana	Anti- inflammatory, Anti-bacterial, Antidiarrheal, Immunomodulatory, Hepatoprotective
Bibhitaki	Vedanasthapana, Deepana, Anulomana, Grahi, Chhardinigrahana, Kaphaghna, Jwaraghna	Antipyretic, Antibacterial, Antidiarrheal, Analgesic, Immunomodulatory, Hepatoprotective
Amalaki	Balya, Deepana, Anulomana, Stambhana, Kaphaghna, Jwaraghna, Rasayana	Antipyretic, Analgesic, Anti-bacterial, Antioxidant,Immunomodulatory, Hepatoprotective
Go Ghrita	Agnideepana, Balya, Ojovardhaka, Rasayana, Ruchya, Vatapittaprashamna, Vayasthapana,	Anti- inflammatory, effect on GIT, Anti-cancer, Antihyperlipidemic

Table 10: Therapeutic indication

SN	Therapeutic Indication	Drug ingredients	Improvement in Clinical Features
1.	Jwaraghna	Madhuka, Chitraka, Haritaki, Bibhitaki, Amalaki	Fever
2.	Pratishyaya	Haritaki, Bibhitaki	Running Nose
3.	Kasaghna	Madhuka, Vacha, Pippali, Haritaki, Bibhitaki, Amalaki	Cough
4.	Dahashamaka	Madhuka, Amalaki	Sore Throat
5.	Shothhara	Pippali, Chitraka, Haritaki, Bibhitaki,	Sore Throat
6.	Udarashoola	Pippali, Chitraka, Haritaki, Amalaki	Pain Abdomen
7.	Chardighna	Madhuka, Bibhitaki	Vomiting
8.	Atisaraghna	Madhuka, Bibhitaki	Loose stools
9.	Deepana-Pachana	Vacha, Pippali (Deepana), Chitraka, Haritaki	Fever, Pain Abdomen
10.	Rasayana	Pippali, Chitraka, Haritaki, Amalaki, Go Ghrita	Immunomodulatory & strengthening
11.	Balya	Madhuka, Pippali, Amalaki, Go Ghrita	Immunomodulatory & strengthening

2. Samangadi Leha

Table 11: Pharmacological actions

Ingredients	Karma	Action based on pharmacological studies
Samanga	Shothahara, Atisaraghna	Anti-microbial, Anti-inflammatory & analgesic, Anti-diarrheal Immunomodulatory Hepatoprotective

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Haritaki	Deepana, Pachana, Anulomana, Grahi, Kaphaghna, Srotah-Shodhana, Rasayana	Anti- inflammatory, Anti-bacterial, Antidiarrheal, Immunomodulatory, Hepatoprotective
Bibhitaki	Vedanasthapana, Deepana, Anulomana, Grahi, Chhardinigrahana, Kaphaghna, Jwaraghna	Antipyretic, Antibacterial, Antidiarrheal, Analgesic, Immunomodulatory, Hepatoprotective
Amalaki	Balya, Deepana, Anulomana, Stambhana, Kaphaghna, Jwaraghna, Rasayana	Antipyretic, Analgesic, Anti-bacterial, Antioxidant,Immunomodulatory, Hepatoprotective
Brahmi	Deepana, Pachana, Vedanasthapana, Shothahara	Anti- inflammatory, Anti-Asthmatic, Immunostimulatory, Gastroprotective, Hepatoprotective
Bala	Rasayana, Kasahara, Vedanahara	Anti- inflammatory Antibacterial, Analgesic, Immunomodulatory, Hepatoprotective
Atibalala	Rasayana, Kasahara, Vedanahara	Analgesic, Antidiarrheal, Wound healing, Immunomodulatory, Hepatoprotective
Chitraka	Deepana, Pachana, Grahi, Kanthya, Jwaraghna, Rasayana	Anti-inflammatory, Antimicrobial, Antioxidant,Nephroprotective, Hepatoprotective
Madhu	Agni Deepaka, Balya, Lekhaniya, Shodhana, Tridoshaprashamana	Anti-bacterial, Anti-oxidant property, source of Dietary fiber, Vit C, Vit.B6
Go Ghrita	Agnideepana, Balya, Ojovardhaka, Rasayana, Ruchya, Vatapittaprashamna, Vayasthapana	Anti- inflammatory, effect on GIT, Anti-cancer, Antihyperlipidemic

Table 12: Therapeutic indication

SN	Therapeutic Indication	Drug ingredients	Improvement in Clinical Features
1.	Jwaraghna	Brahmi, Chitraka, Haritaki, Bibhitaki, Amalaki	Fever
2.	Pratishyaya	Haritaki, Bibhitaki	Running Nose
3.	Kasaghna	Haritaki, Bibhitaki, Amalaki, Brahmi, Bala, Atibala	Cough
4.	Dahashamaka	Amalaki	Sore Throat
5.	Shothhara /Vedanahara	Chitraka, Haritaki, Bibhitaki, Brahmi, Bala, Atibala	Sore Throat
6.	Udarashoola	Chitraka, Haritaki, Amalaki	Pain Abdomen
7.	Chardighna	Bibhitaki	Vomiting
8.	Atisaraghna	Bibhitaki, Bala, Atibala	Loose stools
9.	Deepana-Pachana	Haritaki, Brahmi, Chitraka	Fever, Pain Abdomen
10.	Rasayana	Haritaki, Amalaki, Bala, Atibala, Chitraka, Go Ghrita	Immunomodulatory & strengthening
11.	Balya	Madhu, Amalaki, Go Ghrita	Immunomodulatory & strengthening

Madhukadi Ghrita predominantly exhibits Madhura Rasa, Sheeta Veerya, Snigdha and Guru Guna, and Madhura Vipaka, making it highly nourishing and Vata-Pitta Shamaka. Ingredients like Madhuka, Ghrita, and Amalaki contribute to its immune-strengthening and rejuvenating effects, while Pippali, Vacha, and Chitraka support digestion and metabolism through their Katu Rasa and Teekshana Guna.

Most of the drugs in Samangadi Leha shows a predominance of Kashaya, Tikta, and Madhura Rasa, along with Laghu, Ruksha, and Snigdha Guna, which support detoxification, digestion and nourishment. Its primarily Sheeta Veerya helps pacify Pitta and control inflammation, while Madhura Vipaka promotes Ojas and sustains immunity. The formulation is largely Tridosha Shamaka, with a specific emphasis on Kapha-Pitta pacification, thereby enhancing Vyadhikshamatva in children.

Conclusion

Children with weakened immunity are more prone to recurrent infections, particularly of the respiratory and gastrointestinal tracts, leading to compromised health and development.

The concept of Vyadhikshamatva in Ayurveda emphasizes strengthening the immune response through Balya and Rasayana interventions. Both formulations showed effectiveness in reducing the frequency and severity of recurrent RTIs and GIT disorders. Madhukadi Ghrita (Group I) was more effective in providing rapid symptomatic relief, Samangadi Leha (Group II) had statistically significant result in IgG level, indicating stronger immunomodulatory activity and better long-term immune support. The findings suggest that Samangadi Leha may be better drug of choice for more sustained enhancement of Vyadhikshamatva.

References

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J Ayu Int Med Sci 2025;10(5)19

Research Article

Immunity in Children

Journal of Ayurveda and Integrated Medical Sciences

A Comparative Clinical Study to Evaluate the Efficacy of Madhukadi Ghrita and Samangadi Leha in enhancing Vyadhikshamatva w.s.r. to Immunity in Children

Dharwal R1*, Singh K2, Sharma R3

Introduction

Aim and Objectives

Materials and Methods

Results

Discussion

Conclusion

References

Dharwal R^1*, Singh K², Sharma R³