E-ISSN:2456-3110

Case Report

Nephrotic Syndrome

Journal of Ayurveda and Integrated Medical Sciences

2025 Volume 10 Number 4 APRIL
Publisherwww.maharshicharaka.in

Effectiveness of Ayurveda in Nephrotic Syndrome w.s.r. to Vrikkajanya Sankarya: An Evidence-Based Case Study

Sokiya G1, Benjwal K2*, Giri M3
DOI:10.21760/jaims.10.4.42

1 Gracy Sokiya, Assistant Professor, Department of Kayachikitsa, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar, Uttarakhand, India.

2* Keerti Benjwal, Postgraduate Scholar, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar, Uttarakhand, India.

3 Monika Giri, Postgraduate Scholar, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar, Uttarakhand, India.

As far as Nephrotic Syndrome is considered, it mainly manifests with major protein loss through urine as a cardinal symptom which can be associated with Vrikkajanya Vikara, which is referred to as a type of renal disorder/Vrikka Vikara. A 24-year-old female presented with left lumbar pain, pus in urine, burning micturition, and proteinuria (3+). On the basis of Dosha assessment, Rasayana, Stambhaka, and Mutral Dravyas like Gokhru, Giloy, Chandraprabha Vati, and Ushirasava, including some dietary modifications, were prescribed for two months. Mild improvement was seen in follow ups. This case signifies the importance of early diagnosis and planned ayurvedic interventions in NS to take preventive measures and to keep away from complications and to improve quality of life.

Keywords: Nephrotic syndrome, membranous glomerulonephropathy, Ayurvedic treatment, proteinuria, chronic kidney disease

Corresponding Author How to Cite this Article To Browse
Keerti Benjwal, Postgraduate Scholar, , Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Haridwar, Uttarakhand, India.
Email: 		Sokiya G, Benjwal K, Giri M, Effectiveness of Ayurveda in Nephrotic Syndrome w.s.r. to Vrikkajanya Sankarya: An Evidence-Based Case Study. J Ayu Int Med Sci. 2025;10(4):279-281.
Available From
https://jaims.in/jaims/article/view/4128/

Manuscript Received Review Round 1 Review Round 2 Review Round 3 Accepted
2025-03-12 2025-03-27 2025-04-07 2025-04-17 2025-04-27
Conflict of Interest Funding Ethical Approval Plagiarism X-checker Note
None Nil Not required 11.36

© 2025 by Sokiya G, Benjwal K, Giri M and Published by Maharshi Charaka Ayurveda Organization. This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by/4.0/ unported [CC BY 4.0].

J Ayu Int Med Sci 2025;10(4)279
Download PDFBack To ArticleIntroductionCase ReportMaterials and MethodsResultDiscussionConclusionReferences
Keerti B et al. Effectiveness of Ayurveda in Nephrotic Syndrome

Introduction

A clinical condition known as Nephrotic syndrome has the characteristics of significant proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Focus of this report is on a young female patient who is diagnosed with nephrotic syndrome with an underlying membranous glomerulonephropathy which is confirmed by kidney biopsy. The case signifies the utility of integrative medicine in managing persistent and recurrent symptoms.

Case Report

November 2024

A 24-year-old female presented with:

Chief complaints:

  • Left lumbar pain for 7–8 months
  • Burning micturition
  • Excessive pus in urine

Investigations:

Investigations - Urine profileNovember 2024Follow up December 2024Follow up January 2025 
Urine protein3+3+3+
Leucocyte esterasePositivePositivePositive
Pus cells7-8 HPF14.7012.40
Bacteria Cocci349/HPF262/ HPF36.90
Mucus630130681.00

Kidney Biopsy: 13/07/23 - Membranous glomerulonephropathy, anti-PLA2R positive

Materials and Methods

Initial Treatment: The patient was started on the following Ayurvedic medications:

Giloy Kwath100ml BDEmpty stomach
Gokhru Kwath100 ml BDEmpty stomach
Tab. Renogrit2 tab BDBefore meal
Tab. UTInil2 tab BDBefore meal
Chandraprabha Vati2 tab TDSAfter meal
Vrikkdoshar Vati2 tab TDSAfter meal
UsirasavaEqual amount of water BDAfter meal

December 2024:

The patient returned with the following persistent complaints:

  • Excessive pus in urine
  • Burning micturition
  • Weakness
  • Dizziness
  • Facial swelling in the morning

Revised Treatment: The treatment plan was adjusted to address the worsening symptoms:

UTInil1 tab TDSAfter meal
Basantkusumakar Ras
Hazralyahud Bhasma
Pushyanug Churna
Sphatika Bhasma		1 TSP TDSAfter meal
Punarnavadi Mandoor2 Tab BDAfter meal

January 2025:

During the follow-up in January 2025, the patient reported mild symptomatic relief. However, her primary complaint of pus in urine persisted.

Final Treatment: The medications were further optimized:

Chandraprabha Vati2 tab bdAfter meal
UTInil1 tab BDAfter meal
Basantkusumakar Ras
Hazralyahud Bhasma
Pushyanug Churna
Sphatika Bhasma		1 tsp tdsAfter meal
Chandrakala Ras1 tab TDSAfter meal
Chandanasava
Neeri KFT		Equal amount of water BDAfter meal

Result

By the end of January 2025, the patient reported significant improvement in symptoms, with noticeable relief in urinary complaints. Investigations indicated a reduction in bacteria cocci and mucus levels, though proteinuria (3+) persisted.

Discussion

This case highlights the chronic nature of nephrotic syndrome and its associated complications. The integration of Ayurvedic formulations, including herbal decoctions, mineral-based preparations, and dietary adjustments, appeared to complement symptom management effectively.

Chandraprabha Vati helps to balance the Doshas, improves metabolism and support urinary system health.[1] Ushirasava having antibacterial properties, destroys bacteria in urinary tract causing infections & provides relief from painful urination.[2]


J Ayu Int Med Sci 2025;10(4)280
Keerti B et al. Effectiveness of Ayurveda in Nephrotic Syndrome

Neeri KFT have antioxidant mechanism which alleviate renal and improve kidney function through reducing inflammation.[3]

Chandanasava is highly effective against several bacterial infections, this controls the progression of disease in pt. suffering from UTI and pyuria.[4]

Punarnavadi Mandoor contains drugs that improve liver functioning which is very useful to remove toxins from the body. So, there is proper functioning of Rasa Dhatwagni and Raktadhatwagni which is a very important factor to cure the disease.[5]

Gokhru Kwath - contains Yavakuta powder of Gokhru. Its ethanolic extract has already proved as hepatoprotective and nephroprotective action.[6]

Renogrit tablet - Since, NS has a Pitta dominant Tridosha in its pathology, Renogrit is a compound containing extracts of Varun, Kasni, Pashanbheda, Punarnavamoola, Gokshur, Varuna, Apamarg specifically has Pitta Shamaka properties, Tridoshahara Guna, Madhur Vipaka with Mutral properties and having Tikta Rasa predominant drugs, having properties of igniting Jatharagni to correct out the invariably presenting Mandagni in NS.[7]

The persistence of proteinuria emphasizes the need for long-term monitoring and possibly adjunctive allopathic therapies to prevent further renal damage.

Conclusion

Nephrotic syndrome needs a multidimensional approach, especially in chronic and recurrent cases. This case presents the potential of integrating Ayurvedic therapies for symptomatic relief and improvement in quality of life. Combined efforts and regular follow-ups across medical systems are essential to achieve maximum outcomes.

References

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