Phyto-chemical Standardization of Herbal Formulation (PMM3) for Blood Sugar Attenuating Actions in Streptozotocin induced Rats

  • Dr. Tapas Kumar Sur Post Doctoral Research Scholar, Department of Pharmacology, Institute of Post Graduate Medical Education & Research 244B, AJC Bose Road- 700 020, West Bengal, India.
  • Prabir Kr. Sinha Mahapatra Associate Professor, Dept. of Pharmaceutical Chemistry, Institute of Pharmacy & Technology, Salipur, Orissa, INDIA.
  • Alok K. Hazra Research Officer, Chemistry Division, RKMA Quality Testing Laboratories, Kolkata, West Bengal,
  • Subhas C. Mandal Professor, Division of Pharmacognosy, Dept of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
Keywords: Diabetes, Herbs, Streptozotocin, HPTLC, Quercetin

Abstract

The present study was intended to prepare herbal formulation, PMM3 using purified and modified parts of five common Indian herbs like, Trigonella foenum-graccum, Tinospora cordifolia, Scoparia dulcis, Adhatoda vasica and Cassia occidental. PMM3 was standardized using physico-chemical, phytochemical, UV-VIS spectral, HPTLC, AAS and GC methods. The phenolics and flavonoids contents were assessed. Anti-hyperglycaemic activities of PMM3 was evaluated on Streptozotocin induced (50mg/kg, i.v) diabetic rats. PMM3 (50-150 mg/kg, p.o) exhibited best potentiality in reducing blood glucose within 14 days treatment in comparison with Diabecon® (Himalaya, India) at the same dose. The preset observation identified formulation PMM3 for anti-hyperglycaemic effect.

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CITATION
DOI: 10.21760/jaims.v2i04.235
Published: 2017-08-31
How to Cite
Dr. Tapas Kumar Sur, Prabir Kr. Sinha Mahapatra, Alok K. Hazra, & Subhas C. Mandal. (2017). Phyto-chemical Standardization of Herbal Formulation (PMM3) for Blood Sugar Attenuating Actions in Streptozotocin induced Rats. Journal of Ayurveda and Integrated Medical Sciences, 2(04), 26-33. https://doi.org/10.21760/jaims.v2i04.235
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Original Article