Current management approach of Cancer in Ayurveda

  • Vd. Archana Kashid Assistant Professor, Department of Kayachikitsa, D. Y. Patil School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, India.
Keywords: Ayurveda, Cancer, Granthi, Arbuda, Herbal

Abstract

Ayurveda, the oldest Indian indigenous medicine system of plant drugs is known from very early times for preventing or suppressing various tumors using these natural drugs. In Ayurvedic concept, according to Charaka and Sushruta Samhitas, Cancer is described as inflammatory or noninflammatory swelling and mentioned either as Granthi (minor neoplasm) or Arbuda (major neoplasm). The nervous system (Vata), the venous system (Pitta) and the arterial system (Kapha) are three basics of Ayurveda and very important for normal body function. In malignant tumors all three systems get out of control (Tridoshas) and lose mutual coordination that causes tissue damage, resulting critical condition. Tridoshas cause excessive metabolic crisis resulting in proliferation. The modern cancer therapy which is known to burdened by drug-induced toxic side effects hoping perfect cure of disease form the complementary and alternative medicine system. The main goal of Ayurvedic therapy is to find the ultimate cause of an illness while the therapeutic approach of Ayurveda is divided into four categories as Prakrutisthapana Chikitsa (health maintenance), Rasayana Chikitsa, (restoration of normal function), Roganashani Chikitsa (disease cure) and Naishthiki Chikitsa (spiritual approach). Commonly used herbal decoctions reported in Ayurveda are made of multiple herbs possessing great potential for a cancer cure; scientifically these formulations work on multiple biochemical pathways and influence different organ systems all together and nourish the body as a whole by supporting body‘s deference systems. Now it is important to raise awareness and encourage implementation of Ayurvedic therapies for combating cancer and suggest an integrated approach in tumor management and treatment.

Downloads

Download data is not yet available.

References

Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55:74-108.

Ziegler RG, Hoover RN, Pike MC, et al. Migration patterns and breast cancer risk in Asian –American women. J Natl Cancer Inst 1993;85:1819-27.

Haenszel W, Kurihara M. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the united states.JNatl Cancer Inst 1968;40:43-68.vv

Sharma PV. Charaka Samhita. Varanasi: Choukhamba Orientalia; 1981.

Bhishagratha KL. Sushruta Samhita. Varanasi: Choukhamba Orientalia; 1991.

Prasad GC. Studies on cancer in Ayurveda and its management. JRAS 1987, 3, 147–67.

Singh RM. An assessment of ayurvedic concept of cancer and a new paradigm of anticancer treatment in Ayurveda. J Altern Complement Med 2002, 8, 609– 14.

Sankaran PS. Swellings. In: Prasad GC, Udupa KN, editors. Susruta’s contribution to surgery. Varanasi: Indological Book House, 1976, 99–111.

Sastry JLN. Introduction to oncology, cancer in Ayurveda. Varanasi: Chaukhambha orientalia; 2001, 1– 24

Sonata S. The efficacy of Ayurveda drugs on Cancer (Arbuda). Workshop on cancer souvenir. Chennai: Central Research Institute for Siddha, 1986.

Trivedi N, Rawal UM. Effect of aqueous extract of Andrographis paniculata on liver tumour. Indian J Pharmacol 1998, 30, 318–22.

Trivedi NP, Rawal UM. Hepatoprotective and antioxidant property of Andrographis paniculata in BHC induced liver damage in mice. Indian J ExpBiol 2001, 39, 41– 6.

Singh RP, Bannerjee S, Rao AR. Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolising enzymes and antioxidant status. Phytother Res 2001, 15, 382–90.

Kapil A. Anti hepatoxic effects of major diterpenoid constituents of Andrographis paniculata. BiochemPharmacol 1993, 46, 182–5.

Chih H, Chiu HF, Tang KS, Chang FR, Wu YC. Bullatacin, a potent antitumour annonaceousacetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction. Life Sci 2001, 69, 1321– 31.

Chang FR, Wu YC. Novel cytotoxic annonaceousaceto genins from Annonamuricata. J Nat Prod. 2001, 64, 925–31.

Rajeshkumar NV, Kuttan R. Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma. J Ethnopharmacol 2000, 73, 215–9.

Lee CD, Ott M, Thyagarajan SP, Shafritz DA, Burk RD, Gupta S. Phyllanthus amarus down-regulates hepatitis B virus mRNA transcription and replication. Eur J Clin Invest 1996, 26, 1069–76. 19.

Koul IB, Kapil A. Evaluation of the liver protective potential of piperine. Planta Med 1993, 59, 413–7.

Cavalli F, Tschopp L, Gerber A, Sonntag RW, Ryssel HJ, Brunner KW. Therapiersultatemit VP 16.213 alleinoderkombiniertmit 5-fluorouracil beimleberzellkarzinom (hepatoma), Schweiz. Med Wochenschr 1977, 107, 1960–6.

Pallavacini EB, Porta C, Moroni M, Moroni M, Bertulezzi G, Civelli L, et al. Epirubicin and etoposide combination chemotherapy to treat hepatocellular carcinoma patients: a phase II study. Eur J Cancer 1997, 33, 1784–8.

Nerenstone SR, Ihde DC, Friedman MA. Clinical trials in primary hepatocellular carcinoma: current status and future directions. Cancer Treat Rev 1988, 15, 1–31. 23. Park JG, Lee SH, Hong IG, Kim HS, Lim KH, Choe KJ, et al. MDR1 gene expression its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines. J Natl Cancer Inst 1994, 86, 700–5.

Aita P, Robieux I, Sorio R, Tumolo S, Corona G, Cannizzaro R, et al. Pharmacokinetics of oral etoposide in patients with hepatocellular carcinoma. Cancer Chemother Pharmacol 1999, 43, 287–94.

Sohini YR, Bhatt RM. Activity of a crude extract formulation in experimental hepatic amoebiasis and in immunomodulation studies. J Ethnopharmacol 1996, 54, 119–24.

Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol. 1997, 58, 89–95.

Matthew S, Kuttan G. Immunomodulatory and antitumour activities of Tinospora cordifolia. Fitoterapia 1999, 70, 35–43.

Sharma PV, Chaturvedi C, Bandhopadhyaya NG. A study on dosage and toxicity of Bhallataka (Semecarpus anacardium Linn.). J Res Indian Med 1966, I, 130.

Premalatha B. Semecarpus anacardium Linn. Nuts—a boon in alternative medicine. Indian J Exp Biol 2000, 38, 1177–82.

Cassady JM, Chang CJ, McLaughlin JL. Recent advances in the isolation of structural elucidation of antineoplastic Patel, IJARPB, 2012; Vol.2 (2):179-195. ISSN 2277 – 6222 (Review Article) Available online on www.ijarpb.com Page 194 agents of higher plants. In: Beal JL, Reinhard E, editors. Natural products as medicinal agents.Verlag: Hippokrates; 1981, 93–105.

Chitinis MP, Bhatia KG, Phatak MK, Kesava Rao KV. Antitumour activity of the extract of Semecarpus anacardium L. nuts in experimental tumour models. Indian J ExpBiol 1980, 18, 6–8 .

Premalatha B, Muthulakshmi V, Sachdanandam P. Anticancer potency of the milk extract of Semecarpusanacardium Linn. Nuts against aflatoxin B1 mediated hepatocellular carcinoma bearingWistar rats with reference to tumour marker enzymes. Phytother Res 1999, 13,183–7.

Premalatha B, Sachdanandam P. Effect of Semecarpus anacardium nut milk extract on rat serum alphafetoprotein level in aflatoxin B1 mediated hepatocellular carcinoma. Fitoterapia 1999, 70, 279–83.

Premalatha B, Sachdanandam P. Stabilization of lyzosomal membrane and cell membrane glycoprotein profile by Semecarpus anacardium Linn. Nut milk extract in experimental hepatocellular carcinoma. Phytother Res 2000, 14, 352–5.

Premalatha B, Sachdanandam P. Regulation of mineral status by Semecarpus anacardium Linn. nut milk extract in aflatoxin B1 induced hepatocellular carcinoma. J ClinBiochemNutr 1998, 25, 63–70.

Premalatha B, Sujatha V, Sachdanandam P. Modulating effect of Semecarpus anacardium Linn. nut extract on glucose metabolizing enzymes in aflatoxin B1 induced experimental hepatocellular carcinoma. Pharmacol Res 1997, 36, 187–92.

Premalatha B, Muthulakshmi V, Vijayalakshmi T, Sachdanandam P. Semecarpus anacardium nut extract induced changes in enzymic antioxidants studied in aflatoxin B1 caused hepatocellular carcinoma bearing Wistar rats. Int J Pharmacog 1997, 35, 1–6.

Premalatha B, Sachdanandam P. Semecarpus anacardium L nut extract administration induces the in vivo antioxidant defense system in aflatoxin B1 mediated hepatocellular carcinoma. J Ethnopharmacol 1999, 66, 131–9.

Premalatha B, Sachdanandam P. Potency of Semecarpus anacardium Linn. nut milk extract against aflatoxin B1 induced hepato carcinogenesis:reflection on microsomal biotransformation enzymes. Pharmacol Res 2000, 42, 161–6.

Premalatha B, Sachdanandam P. Modulating role of Semecarpus anacardium L. nut milk extract on aflatoxin B1 biotransformation. Pharmacol Res 2000, 41, 19–24.

Premalatha B, Sachdanandam P. Effect of Semecarpus anacardium nut extract against aflatoxin B1 induced hepatocellular carcinoma. Fitoterapia 1999, 70, 484–92

Vad BG. Study of complete regression in four cases of cancer. The Indian Practitioner 1973, 26, 253–63. 43. Bakhru HK. Conquering cancer naturally. Delhi: Chaukhamba Sanskrit Pratishthan; 2000, 1–6.

Balachandran P, Govindarajan R. Cancer: An ayurvedic perspective. Pharmacol Res. 2005;51:19–30. [PubMed] 45. Patel B, Das S, Prakash R, Yasir M. Natural bioactive compound with anticancer potential. Int J Advan Pharmaceut Sci. 2010;1:32–41.

Roshy Joseph C, Illanchezhian R, Jocob Raymond CJ. Arbuda –The concept of cancer in Ayurveda AyurpharmInt J Ayur Alli Sci. 2016;5(4) :47-51.
CITATION
DOI: 10.21760/jaims.v2i03.197
Published: 2017-06-30
How to Cite
Vd. Archana Kashid. (2017). Current management approach of Cancer in Ayurveda. Journal of Ayurveda and Integrated Medical Sciences, 2(03), 113-120. https://doi.org/10.21760/jaims.v2i03.197
Section
Review Article